Depolarization and hyperpolarization their relationship to threshold

Hyperpolarization (biology) - Wikipedia

depolarization and hyperpolarization their relationship to threshold

There are many details, but go slow and look at the figures. When the depolarization reaches about mV a neuron will fire an action potential. Also , when the threshold level is reached, an action potential of a fixed sized will always The action potential actually goes past mV (a hyperpolarization) because the. The intensity of the depolarizing and hyperpolarizing DC was set as a percentage of Relationship between accommodation and the driving threshold change. In response to the appropriate stimulus, the cell membrane of a nerve cell goes of depolarization from its rest state followed by repolarization to that rest state. Once the threshold is reached, more sodium gates open and Na+ ions flood into the cell Hyperpolarization prevents the neuron from receiving another stimulus .

The hyperpolarization following an inhibitory stimulus causes a further decrease in voltage within the neuron below the resting potential.

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By hyperpolarizing a neuron, an inhibitory stimulus results in a greater negative charge that must be overcome for depolarization to occur. Excitation stimuli, on the other hand, increases the voltage in the neuron, which leads to a neuron that is easier to depolarize than the same neuron in the resting state.

Regardless of excitatory or inhibitory, the stimuli travel down the dendrites of a neuron to the cell body for integration.

depolarization and hyperpolarization their relationship to threshold

Integration of stimuli[ edit ] Summation of stimuli at an axon hillock Once the stimuli have reached the cell body, the nerve must integrate the various stimuli before the nerve can respond. The stimuli that have traveled down the dendrites converge at the axon hillockwhere they are summed to determine the neuronal response.

If the sum of the stimuli reaches a certain voltage, known as the threshold potentialdepolarization continues from the axon hillock down the axon. Response[ edit ] The surge of depolarization traveling from the axon hillock to the axon terminal is known as an action potential. Action potentials reach the axon terminal, where the action potential triggers the release of neurotransmitters from the neuron.

The neurotransmitters that are released from the axon continue on to stimulate other cells such as other neurons or muscle cells. After an action potential travels down the axon of a neuron, the resting membrane potential of the axon must be restored before another action potential can travel the axon.

This is known as the recovery period of the neuron, during which the neuron cannot transmit another action potential. Rod cells of the eye[ edit ] The importance and versatility of depolarization within cells can be seen in the relationship between rod cells in the eye and their associated neurons.

depolarization and hyperpolarization their relationship to threshold

When rod cells are in the dark, they are depolarized. In the rod cells, this depolarization is maintained by ion channels that remain open due to the higher voltage of the rod cell in the depolarized state.

depolarization and hyperpolarization their relationship to threshold

The ion channels allow calcium and sodium to pass freely into the cell, maintaining the depolarized state. Rod cells in the depolarized state constantly release neurotransmitters which in turn stimulate the nerves associated with rod cells. This cycle is broken when rod cells are exposed to light; the absorption of light by the rod cell causes the channels that had facilitated the entry of sodium and calcium into the rod cell to close.

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When these channels close, the rod cell produces less neurotransmitter, which is perceived by the brain as light. In the case of rod cells and neurons, depolarization actually prevents a signal from reaching the brain as opposed to stimulating the transmission of the signal. The endothelium that lines blood vessels is known as vascular endothelium, which is subject to and must withstand the forces of blood flow and blood pressure from the cardiovascular system.

To withstand these cardiovascular forces, endothelial cells must simultaneously have a structure capable of withstanding the forces of circulation while also maintaining a certain level of plasticity in the strength of their structure. This plasticity in the structural strength of the vascular endothelium is essential to overall function of the cardiovascular system. Endothelial cells within blood vessels can alter the strength of their structure to maintain the vascular tone of the blood vessel they line, prevent vascular rigidity, and even help to regulate blood pressure within the cardiovascular system.

Endothelial cells accomplish these feats by using depolarization to alter their structural strength. When an endothelial cell undergoes depolarization, the result is a marked decrease in the rigidity and structural strength of the cell by altering the network of fibers that provide these cells with their structural support.

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Depolarization in vascular endothelium is essential not only to the structural integrity of endothelial cells, but also to the ability of the vascular endothelium to aid in the regulation of vascular tone, prevention of vascular rigidity, and the regulation of blood pressure.

The sinoatrial SA node on the wall of the right atrium initiates depolarization in the right and left atria, causing contraction, which is symbolized by the P wave on an electrocardiogram. The SA node sends the depolarization wave to the atrioventricular AV node which—with about a ms delay to let the atria finish contracting—then causes contraction in both ventricles, seen in the QRS wave.

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At the same time, the atria re-polarize and relax. The ventricles are re-polarized and relaxed at the T wave. This process continues regularly, unless there is a problem in the heart. However, an action potential can travel down the length of a neuron, from the axon hillock the base of the axon, where it joins the cell body to the tip of the axon, where it forms a synapse with the receiving neuron. Anatomy of a neuron This directional transmission of the signal occurs for two reasons: These ions spread out laterally inside the cell and can depolarize a neighboring patch of membrane, triggering the opening of voltage-gated sodium channels and causing the neighboring patch to undergo its own action potential.

The refractory period is primarily due to the inactivation of voltage-gated sodium channels, which occurs at the peak of the action potential and persists through most of the undershoot period.

These inactivated sodium channels cannot open, even if the membrane potential goes above threshold. The slow closure of the voltage-gated potassium channels, which results in undershoot, also contributes to the refractory period by making it harder to depolarize the membrane even once the voltage-gated sodium channels have returned to their active state. The refractory period ensures that an action potential will only travel forward down the axon, not backwards through the portion of the axon that just underwent an action potential.

depolarization and hyperpolarization their relationship to threshold

When the action potential reaches the end of the axon the axon terminalit causes neurotransmitter-containing vesicles to fuse with the membrane, releasing neurotransmitter molecules into the synaptic cleft space between neurons. When the neurotransmitter molecules bind to ligand-gated ion channels on the receiving cell, they may cause depolarization of that cell, causing it to undergo its own action potential.

Some neurotransmitters also cause hyperpolarization, and a single cell may receive both types of inputs.

Hyperpolarization (biology)

I hope that helps! Good luck with your finals studying!

depolarization and hyperpolarization their relationship to threshold

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