tall tropical American timber tree especially abundant in eastern Brazil; yields hard strong durable zebrawood with straight grain and dark strips on a pinkish to . Gonçalo Alves ou Gonçaleiro (Astronium fraxinifolium) Família Anacardiaceae. Árvore rústica de médio porte, comum em várias regiões, ás vezes chamada de. PDF | Essential oils produced from leaves of Astronium fraxinifolium Schott. harvested at four different stages of maturity have been analyzed by GC/MS.

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Nonetheless, in some cases when mucosa, such as nasal or oral mucosa, is fradinifolium, treatment is necessary; otherwise, permanent sequelae may occur [ 7 ].

BioMed Research International

No cytotoxic activity of the plant materials was observed when they were incubated in different concentrations with RAW As it was shown in our previous study [ 26 ], the major component in essential oil obtained from P.

American cutaneous leishmaniasis is a form of disease that causes a single or various cutaneous asttonium that can heal spontaneously. The analyses were performed using GraphPad Prism version 5.

However, a higher number of parasites were found when the group of animals treated with the plant material was compared with the group treated with Glucantime. Early diagnosis aetronium treatment are important to prevent sequelae. Trypsin was inactivated by adding the same volume of medium containing foetal bovine serum.

Astronium fraxinifolium Images – Useful Tropical Plants

Pentavalent antimonials are still the treatment of choice for over 50 years; however, they comprise several problems, such as endovenous use and prolonged and high-cost treatment [ 10 ]. In vitro antileishmanial activity of essential oil of P. Antileishmanial Evaluation The in vitro evaluation of the antileishmanial activity of the essential oil from P.

The major component of the essential oil was carvacrol. The number of parasites in the lesions was quantified by the limiting dilution technique as previously described [ 30 ].


The authors declare that there is no conflict of interests regarding the publication of this paper. According to their data, mice infected with L. Several studies have been fraxinifoolium confirming much of the popular use of Plectranthus amboinicussuch as anti-inflammatory and antimicrobial activities [ 23 — 27 ]. The arrow indicates start of treatment about the 27th day.

The treatment was initiated when the lesions appeared about the 27th day. Furthermore, the continuous use of ineffective drugs has led to the development of resistance to their compounds [ 16 ], which have stirred an urgent need for novel, effective, and safe drugs for treatment of leishmaniasis.

Carvacrol is a monoterpene phenol, isomer to thymol, and presents various biological activities such as antimicrobial, antitumor, and anti-inflammatory activities [ 32 ]. Also, male animals were tested because this gender is more susceptible to the Leishmania infection than the females, and this susceptibility satronium to be related to the type of cytokine produced [ 35 ].

Astronium fraxinifolium Schott Anacardiaceae Some works treat this species as a form or just a synonym of Astronium graveolens. Fruiting branch Photograph by: View at Google Scholar E.

Treatment was done by administering OEPA intralesionally i. Now containing plants. Awtronium Vivo Studies 2. Increased incidence of resistance to the drug has been described ashronium 8 ]. The animals were treated with leaf ethanolic extract from Astronium fraxinifolium EEF.

Assays were performed in triplicate. After the 7th week of infection, the lesion thickness in the group treated with the plant material was below the limit of normal thickness. The essential oil of P. The uninfected contralateral footpad was also intralesionally injected with the same solution used for treatment. The strain of L.

Astronium fraxinifolium – Wikipedia

Results and Discussion In ftaxinifolium present study we decided to evaluate two medicinal plants, Plectranthus amboinicus and Astronium fraxinifolium. The in vitro evaluation of the antileishmanial activity of the essential oil from P. View at Google Scholar F.


The ethanolic extracts of the bark, sapwood, and leaves of A.

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Additionally, we decided to use the gold hamster model to evaluate the activity of our plant materials in vivo based on the fact that hamsters are known to be highly susceptible to Leishmania subgenus Viannia infection [ ftaxinifolium ]. On the other hand, all the ethanolic extracts from bark, sapwood, and leaves from A. Macrophage cell line RAW Various factors contribute to the increase of the disease incidence, for instance, the process of urbanization which alters the environment in decurrence of economic and social pressures [ 5 ].

For each experiment, cells were removed from the culture medium and incubated with 0. Leishmaniasis is a disease that affects human beings and animals and is caused by the protozoa parasite of the genus Leishmania which is transmitted by the bite of infected female phlebotomine sandflies and displays a spectrum of manifestations which goes from astroniym involvement CL with late destruction of mucous membranes to generalized systemic visceral disease VL with fatal outcome if not treated [ 1 ].


Treatment with the Essential Oil of P. A superb work, with the minor irritation that the translation from Portuguese is not of the best. This fact could be related to the concentration of the essential oil, to the route of administration, or even to the period of treatment.

In respect to parasite growth, the animals treated with the plant material showed lower parasites in the infected footpad after treatment in wstronium to the untreated animals Figure 4 b .