Phenytoin Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side. Page 1. Page 4. Malta ADR Reporting website: adrportal 5. How to store Epanutin RMP The storage of Epanutin RMP will not be . Epanutin Injection is used for Seizure, Migraine, Cardiac arrhythmias and other conditions. Epanutin Injection may also be used for purposes not listed in this.

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Continuous monitoring epannutin electrocardiogram, blood pressure and respiratory function for the duration of the infusion is essential. Pro-Epanutin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin.

There is a risk of potentially fatal respiratory or circulatory depression. Pro-Epanutin may result in a failure of hormonal contraceptives, hence women of childbearing potential should be counselled regarding the use of other effective contraceptive methods see section 4.

Pro-Epanutin Concentrate for Infusion / Solution for Injection

Antagonizes tricyclic antidepressants, oral anticoagulants, oral contraceptives, estrogens, corticosteroids, doxycycline, digitoxin, furosemide, theophylline, rifampin, quinidine, vitamins D and K, others.

Several individual case reports have suggested that there may be an increased, although still rare, incidence of hypersensitivity reactions, including skin rash and hepatotoxicity, in black patients.

See Table 5 for infusion times. What are the side-effects of Epanutin Injection?

Skin and subcutaneous tissue disorders. When inuection intramuscular administration is necessary for a patient previously stabilised orally, compensating dosage adjustments are essential to maintain therapeutic serum levels.


Phenytoin is also a potent inducer of hepatic drug-metabolising enzymes and may reduce the levels of drugs metabolized by these enzymes.

Epanutin Injection – Uses, Side-effects, Reviews, and Precautions – TabletWise – UAE

Women planning to become pregnant and in pregnant women In women planning to become pregnant all efforts should be made to switch to appropriate alternative treatment prior to conception, if possible.

This site uses injwction. In patients with acute hepatotoxicity, fosphenytoin should be immediately discontinued and not re-administered.

Usually, government’s categorizes medicines that can be addictive as controlled substances. Phenytoin hepatic metabolism is saturable and, following administration of single IV Pro-Epanutin doses of to mg PE, total and unbound phenytoin AUC values increase disproportionately with dose.

Fosphenytoin can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome SJSand toxic epidermal necrolysis TENwhich can be fatal. Neurodevelopmental disorder has been reported among children born to women with epilepsy who took phenytoin alone or in combination with other AEDs during pregnancy. As a general principle, monotherapy is preferred for treating epilepsy in pregnancy whenever possible because therapy with multiple AEDs could be associated with a higher risk of congenital malformations than monotherapy, depending on the associated AEDs.

The syndrome may not develop for several days after injection. Dosage and dosing interval will, of necessity, be determined by the needs of the individual patient.

Phenytoin Injection Dosage & Rx Info | Uses, Side Effects – MPR

Last updated on eMC: Epanutin Injection may also be used for purposes not listed in this medication guide. Thyroid function test abnormal. Intravenous IV Infusion rate Adults: Serum levels of phenytoin can be reduced by concomitant use of the herbal preparations containing St.


Cases of acute hepatotoxicity, including infrequent cases of acute hepatic failure, have been reported with phenytoin. It appears to stabilise rather than raise the seizure threshold and prevents spread of seizure activity rather than abolish the primary focus of seizure discharge.


Periodic measurement of plasma phenytoin concentrations may be valuable in the management of pregnant women as a guide to appropriate adjustment of dosage see section 4. Epanutin RMP can be used to treat severe epileptic seizures or fits status epilepticus.

While the clearance rate of total phenytoin is not affected, the plasma unbound phenytoin concentrations may be elevated. In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5.

Intramuscular phenytoin administration may cause pain, necrosis, and abscess formation at the injection site see section 4.

This site uses cookies. There have been a number of reports suggesting eepanutin relationship between phenytoin and the development of lymphadenopathy local or generalised including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin’s disease.