Each film-coated tablet of Levofloxacin mg Film-coated Tablets contains mg of levofloxacin equivalent to mg of levofloxacin hemihydrate. Name: Levofloxacin hemihydrate; Drug Entry: Levofloxacin. A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling. Find patient medical information for Levofloxacin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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The degree of the bactericidal activity of levofloxacin oevofloxacin on the ratio of the maximum concentration in serum C max or the area under the curve AUC and the minimal inhibitory concentration MIC. The tablets may be taken during meals or between meals. The identification and antimicrobial susceptibility tests on any such isolate must be repeated and if the result is confirmed the isolate must be sent to a reference laboratory.

Food has little effect on the absorption of levofloxacin.

Other relevant information Clinical pharmacology studies have shown that the pharmacokinetics of levofloxacin were not affected to any clinically relevant extent when levofloxacin was administered together with the following drugs: As ofJohnson and Johnson was facing around state and federal lawsuits filed by people who claimed tendon damage from levofloxacin; about pending hemihydeate a class action at the United States District Court in Minnesota [64] and about pending at a district court in New Jersey.


FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side levofloxacij that can occur”.


There are limited amount of data from the use of levofloxacin in pregnant women. Jaundice and severe liver injury, including cases with fatal acute liver failure, primarily in patients with severe underlying diseases see section 4.

Visual disturbances such as blurred vision see section 4.

The bioavailability of Levofloxacin mg Film-coated Tablets is significantly reduced when administered together with sucralfate. Caution is recommended if levofloxacin is to be used in psychotic patients or oevofloxacin patients with history of psychiatric disease. Probenecid and cimetidine Probenecid and cimetidine had a statistically significant effect on the elimination of levofloxacin.

Levofloxacin Hemihydrate (CAS 138199-71-0)

Other forms of interactions Food There is no clinically relevant interaction with food. C Risk not ruled out. The use of non-steroidal anti-inflammatory drugs NSAIDs in combination with high dose fluoroquinolone therapy may lead to seizures.

Levofloxacin is marketed by Sanofi-Aventis under a license agreement signed with Daiichi in under hemihudrate trade name “Tavanic”. Similar results have been reported when levofloxacin is taken with iron supplements and multi-vitamins containing zinc.

By using this site, you agree to the Terms of Use and Privacy Policy. Package inserts mention that levofloxacin is to be avoided in patients with a known hypersensitivity to levofloxacin or other quinolone drugs. Studies in the mouse showed levofloxacin to have phototoxic activity only at very high doses. Archived from the original on 2 February According to toxicity studies in animals or clinical pharmacology studies performed with supra-therapeutic doses, the most important signs to be expected following acute overdose of levofloxacin tablets are central nervous system symptoms such as confusion, dizziness, impairment of consciousness and convulsive seizures, increases in QT interval as well as gastro-intestinal reactions such as nausea and mucosal hemihdrate.


Levofloxacin mg Film-coated Tablets – Summary of Product Characteristics (SmPC) – (eMC)

DNA gyrase, on the other hand, is responsible for supercoiling the DNA, so that it will fit in the newly formed cells. Levofloxacin is contraindicated in patients with a history of epilepsy see section 4.

Retrieved from ” https: Archived from the original on 5 November It is recommended that patients should not expose themselves unnecessarily to strong sunlight or to artificial UV rays e. Toxic epidermal necrolysis Stevens-Johnson syndrome Erythema multiforme Hemihydrare reaction see section 4.

Levofloxacin acts as a bactericide.

Psychotic reactions Psychotic reactions have been reported in patients receiving quinolones, including levofloxacin. In case of convulsive seizures see section 4. Levofloxacin is not recommended in patients with a known history of myasthenia gravis. These effects can be attributed to inhibition of topoisomerase II.

Levofloxacin mg Film-coated Tablets is contraindicated in children and growing adolescents see section 4.